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Symbol
Name
ID

Tlr7
toll-like receptor 7
MGI:2176882

Phenotype annotations related to hematopoietic system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

hematopoietic system phenotype

decreased B cell apoptosis

decreased B cell proliferation

decreased splenocyte proliferation

increased splenocyte proliferation

enlarged spleen

spleen hyperplasia

extramedullary hematopoiesis

anemia

thrombocytopenia

increased germinal center B cell number

decreased follicular B cell number

decreased marginal zone B cell number

increased mature B cell number

increased marginal zone B cell number

increased plasma cell number

increased B cell number

increased effector memory CD4-positive, alpha-beta T cell number

increased T follicular helper cell number

increased CD4-positive, alpha-beta T cell number

decreased leukocyte cell number

abnormal dendritic cell morphology

abnormal B cell morphology

abnormal mature B cell morphology

abnormal spleen morphology

increased spleen germinal center number

decreased spleen white pulp amount

abnormal B cell physiology

abnormal B cell activation

decreased IgG1 level

decreased IgG2a level

decreased IgG level

decreased IgM level

abnormal T cell activation

abnormal macrophage physiology

Availability

Mouse Genotype

Tlr7^em2Anu/Tlr7^em2Anu

Tlr7^rsq1/Tlr7^rsq1

Tlr7^tm1Aki/Tlr7^tm1Aki

*

Tlr7^tm1Flv/Tlr7^tm1Flv

Tlr8/Tlr7^tm1Vlcg/Tlr8/Tlr7^tm1Vlcg

Tlr7^em2Anu/Tlr7⁺

Tlr7^em2Anu/Y

Tlr7^rsq1/Y

Tlr7^rsq2/Y

Tlr7^tm1Flv/Y

X/Tg(Tlr7)6Boll

Tg(Tlr7)1Boll/0

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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